The relationship between serum preS1 level and liver fibrosis in patients with chronic hepatitis B and the diagnostic value of liver cancer
GAO Xingjuan
CHENG Lei
MA Xiuqing
LIU Shouzhu
WANG Baoying
LIU Haiyan
CAI Deji
YANG Xingtang
Abstract：Objective To analyze the correlation between serum hepatitis B virus(HBV)precursor S1 protein(preS1)and liver fibrosis and disease progression in chronic hepatitis B(CHB).Methods A total of 228 patients with hepatitis B surface antigen(HBsAg)positive chronic HBV infection examined in our hospital from October 2019 to October 2021 were analyzed retrospectively,including 73 patients with CHB,93 patients with liver cirrhosis(LC),60 patients with hepatocellular carcinoma(HCC).Liver fibrosis and inflammatory activity was analyzed by liver biopsy.Results Serum preS1 level in HCC group[496.32(457.63,988.0)ng/mL]and LC group[338.72(247.93,554.61)ng/mL]were significantly higher than those in CHB group[113.69(87.09,177.40)ng/mL](P＜0.001).The serum preS1 level in HCC group was also higher than that in LC group(P=0.002).According to receiver operating characteristic curve analysis,the area under the curve of serum preS1 level to differential diagnosis LC vs.CHB group or HCC vs.LC+CHB group was 0.881(95%CI:0.830～0.932)and 0.861(95%CI:0.815～0.908),respectively.Serum preS1 level were strongly positively correlated with HBsAg(rs=0.799,P＜0.001)and weakly positively correlated with Log HBV DNA(rs=0.262,P＜0.001)in patients with CHB,LC and HCC.Additionally,serum preS1 level was also weakly positively correlated with liver inflammatory activity grade(rs=0.201,P=0.009)and liver fibrosis stage(rs=0.295,P＜0.001)in LC group and HCC group.Conclusion The serum preS1 level is correlated with the levels of HBV markers in the serum HBsAg and HBV DNA levels,as well as the progression of liver inflammation and fibrosis.Therefore,it has the potential to serve as a valuable biomarker for distinguishing between cirrhosis and canceration in patients with HBV-associated chronic liver disease.
Keywords：hepatitis B virusHBV pre-S1 proteinchronic hepatitis bliver fibrosisliver inflammatory activityhepatocellular carcinoma
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 132-136 )