Analysis of pathogenic bacteria distribution and risk factors of lower respiratory tract infection caused by radiotherapy and chemotherapy in elderly patients with non-small cell lung cancer
KONG Wenjie
LI Baoliang
ZOU Fang
GAO Jing
XIE Xiaojuan
Abstract：Objective To analyze the distribution of pathogenic bacteria and risk factors of lower respiratory tract infection in elderly patients with non-small cell lung cancer ( NSCLC ) undergoing radiotherapy and chemotherapy. Methods A retrospective analysis was performed on 108 elderly NSCLC patients undergoing radiotherapy and chemotherapy in our hospital. According to whether they developed lower respiratory tract infection, they were divided into infection group ( 40 cases ) and non-infection group ( 68 cases ). Pathogenic bacterial cultures were performed on collected secretions. At the same time, data on the related factors of lower respiratory tract infection were collected, and conducted univariate and multivariate Logistic regression analyses. Results In NSCLC patients, the incidence of lower respiratory tract infection was 37.04％, which was higher than the average level of nosocomial infection in our hospital in recent years ( the average infection rates from 2019 to 2022 were 8.39％, 8.05％, 8.17％, and 7.04％, respectively ). The proportion of patients aged≥70 years, with diabetes, TNM stage Ⅲ and Ⅳ, hospitalization time >15 d, and CD4+/CD8+ ratio≤1 in the infection group was higher than that in the non-infection group, and the difference was statistically significant ( P<0.05 ). Age ≥70 years, CD4+/CD8+ ratio ≤1, hospitalization time >15 d, TNM stage Ⅲ and Ⅳ were the risk factors of lower respiratory tract infection in elderly NSCLC patients undergoing radiotherapy and chemotherapy ( OR=1.574, 2.416, 3.995, 2.186, P < 0.05 ). Conclusions The pathogenic bacterial spectrum of lower respiratory tract infection in elderly NSCLC patients undergoing radiotherapy and chemotherapy has no significant change in recent years. Old age, low CD4+/CD8+ ratio, long hospitalization time and high TNM stage are the risk factors of lower respiratory tract infection in patients.
Keywords：non-small cell lung cancerelderly patientsradiotherapy and chemotherapylower respiratory tract infectionpathogenic bacteriarisk factor
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 61-64,69 )