Diagnostic value of ultrasound elastography combined with serum Mac-2 binding protein glycosylation isomer and NADPH oxidase 2 for hepatic fibrosis in patients with chronic hepatitis B
TAN Yaling
WANG Changqing
WU Zhenbao
MING Quan
Abstract：Objective To investigate the diagnostic value of ultrasound elastography combined with serum Mac-2 binding protein glycosylation isomer ( M2BPGi ) and reduced nicotinamide adenine dinucleotide phosphate oxidase 2 ( NOX2 ) for liver fibrosis in chronic hepatitis B ( CHB ) patients, to provide a reference basis for the diagnosis of liver fibrosis. Methods A total of 175 patients with CHB admitted to The Third People's Hospital of Yichang City from January 2021 to March 2023 were regarded as the study subjects, and the involved patients were divided into non-significant liver fibrosis group ( n=67 ) and significant liver fibrosis group ( n=108 ) based on the degree of liver fibrosis. Multivariate Logistic regression analysis method was applied to analyze the influencing factors of significant liver fibrosis; Receiver operating characteristic ( ROC ) analysis was applied to analyze the diagnostic value of ultrasound elastography combined with serum levels of M2BPGi and NOX2 for significant liver fibrosis. Results The levels of alanine aminotransferase ( ALT ), aspartate aminotransferase ( AST ), albumin ( ALB ) and platelet count ( PLT ) were significantly different between non-significant hepatic fibrosis group and significant hepatic fibrosis group ( P <0.05 ); compared with the non-significant liver fibrosis group, the MEAN and KURT were obviously lower in the significant liver fibrosis group ( P<0.05 ), while the SKEW, COMP, CONT, SD, AREA, and serum M2BPGi and NOX2 levels were obviously higher ( P <0.05 ); Serum M2BPGi, NOX2, ALT, COMP, and AREA were independent risk factors for significant liver fibrosis in CHB patients, while PLT and MEAN were protective factors ( P < 0.05 ). ROC results showed that the AUC of M2BPGi, NOX2, MEAN, COMP and AREA combined diagnosis of significant hepatic fibrosis was 0.933, which was significantly higher than that of single diagnosis ( P < 0.05 ). Conclusion M2BPGi and NOX2 have higher levels in the serum of CHB patients with significant liver fibrosis, and their combination with ultrasound elastography has high diagnostic value for significant liver fibrosis.
Keywords：ultrasound elastographyMac-2 binding protein glycosylation isomerreduced nicotinamide adenine dinucleotide phosphate oxidase 2chronic hepatitis Bliver fibrosisdiagnostic value
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 16-20,40 )