Correlation analysis of baseline HIV RNA and immune function reconstitution in patients who receive antiviral regimen contained efavirenz
PANG Zhenzhen
HUANG Xiaohong
GU Jinhua
YAN Haiyan
WEI Huifen
QIN Xiangsong
JIANG Zhongsheng
Abstract：Objective To investigate the correlation between baseline HIV load(VL)and immune function reconfiguration by observing the changes in CD4+ T lymphocyte counts during antiviral therapy contained efavirenz(EFV)regimen in AIDS patients with different baseline VL level.Methods The study enrolled initial treatment adult AIDS patients who were followed up and managed at the Care Clinic of Liuzhou People's Hospital from 2010 to 2020.All patients received antiviral treatment contained EFV with the observation period of 120 months.According to the receiver operating characteristic curve,the optimal cut-off value of baseline VL was calculated in predicting immune function reconstruction.All patients were divided into low baseline VL group and high baseline VL group based on the optimal cut-off value.The relationship between different baseline VL groups and immune function reconstruction was analyzed by the generalized estimation equation(GEE).Results The optimal cut-off value of baseline VL in predicting immune reconstitution was 5.533×104 copies/mL.The success rate of immune reestablishment in the low baseline VL group(87.58%)was higher than that in the high baseline VL group(70.93%)(P＜0.05).The analysis of GEE showed that there was a statistically significant difference in CD4+ T lymphocyte counts between the low baseline VL group and the high baseline VL group(Wald χ2=24.789,P=0.000)and there were significant differences among different follow-up times(Wald χ2 =911.501,P=0.000).Conclusion The immune function recovery and reconstruction effect of contained EFV regimen is better when the baseline VL of AIDS patient was low than 5.533×104 copies/mL.
Keywords：acquired immune deficiency syndromeefavirenzimmune reconstitutionviral loadCD4+ T lymphocytes
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 512-516 )