Application of Mendelian randomization in the study of risk factors for primary liver cancer
DONG Xu
XUE Jianya
LIANG Xuesong
Abstract：Primary liver cancer(PLC)is one of the most common malignant tumors with high morbidity and mortality.Early identification of risk factors for PLC patients could help alleviate the national healthcare burden.Mendelian randomization(MR),which takes genetic variation as an instrumental variable,has been widely used in recent years due to its ability to address confounding biases often encountered in traditional observational studies.This method is effective and reliable in the association of genetic risk factors by utilizing independent results from two genome-wide association studies within the same population.It has been applied to evaluate potential causal links between a variety of tumors and gut microbiota,lifestyle,underlying diseases,etc.In this paper,we provide a comprehensive review of the application of MR in identifying risk factors for PLC,aiming to provide valuable insights for early prevention and control strategies.
Keywords：Mendelian randomizationprimary liver cancerrisk factorsgenome-wide association studiesintestinal florametabolic syndrome
Publication Date：2023-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 473-476,480 )