Role of perforin and granzyme B in different immune status of hepatitis B
HU Linhui
CHENG Hao
YAO Tiantian
QIAN Jiandan
DONG Linfei
WANG Guiqiang
WANG Yan
Abstract：Perforin(PFN)is a glycoprotein that present in cytotoxic cells(also known as killer cells,including natural killer cells,cytotoxic T cells and so on),and granzyme B(Gzm B)is a small molecular protein that expressed in cytotoxic cells.PFN and Gzm B reserves in cytoplasmic particles of cytotoxic cells and released by exocytosis after contact with target cells.As two important effector molecules of cytotoxic cells,PFN and Gzm B play important roles in the various types of liver injury against immune response.Among various of liver injury,the liver injury caused by hepatitis B is studied well.The interaction between hepatitis B virus(HBV)replication and host antiviral immunity determines the outcome of HBV infection,PFN and Gzm B are the important mediators of pathogen clearance and apoptosis of target cells in viral infection.The expression levels of PFN and Gzm B are showed different characteristics in different stages of hepatitis B virus infection:In acute HBV infection,cytotoxic T cells(CTL)highly express PFN and Gzm B;In chronic HBV infection,natural killer cells(NK cells),CTL expression of PFN and Gzm B were down-regulated;In the stage of severe hepatitis B,the up-regulation of PFN and Gzm B that expressed by CTL may aggravate the HBV infection.This article mainly introduces the specific functions of PFN and Gzm B in different immune status during the immune stage of HBV infection.
Keywords：perforingranzyme Bcytotoxic T cellsnatural killer cellhepatitis Bliver injuryapoptosissevere HBV infection
Publication Date：2023-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 458-462,468 )