Clinical analysis of 427 HIV/AIDS patients complicated with HCV infection

QIN Yaqin; LI Yanjun; ZHANG Chao; LUO Feng

doi:10.3969/j.issn.1007-8134.2023.05.007

Abstract：Objective To explore the current situation and clinical characteristics of HCV coinfection in hospitalized HIV/AIDS patients in Guangxi.Method A retrospective analysis was conducted on 13 142 HIV/AIDS patients who were hospitalized for the first time in our hospital from 2018 to 2022,to explore the infection rate,infection pathway,and direct-acting antivirals(DAAs)treatment status of HCV comorbidities;We included 354 patients with simple HCV infection admitted during the same period as controls to analyze the incidence and mortality of severe liver disease.Results Among the 13 142 HIV/AIDS patients,427 were co-infected with HCV,with an infection rate of 3.25％.Eighty-five point seven one percent of the HIV/HCV group had a history of multiple female partners.Liver failure and fatality incidence were significantly higher than that of the HCV group(P＜0.05).Forty-nine cases of HIV/HCV coinfection were genotyped and found to be 1a type 19.61％,lb type 13.73％,2a type 3.92％,3a type 11.76％,3b type 17.65％,6a type 29.41％,6d type 1.96％,and 6e type 1.96％.Only 1.41％of 427 AIDS patients with HCV infection received DAAs before admission.A survey was conducted on the reasons for not receiving treatment among 106 HIV/HCV coinfected cases:53.77％of farmers,34.91％of urban residents without fixed employment;64.15％of patients were found to be positive for hepatitis C during their first hospital examination;Hepatitis C has been discovered outside the hospital for many years,but 83.78％of them are unwilling to receive treatment.Conclusions The proportion of HIV/AIDS combined with HCV infection is high in Guangxi,and sexual transmission is the leading cause of combined HCV infection.HCV genotypes are mainly types 1,3,and 6.HIV and HCV coinfection can easily lead to severe liver disease and increased mortality.The DAAs treatment rate before admission is low.Therefore,in case of combined HCV infection,education should be strengthened,compliance should be improved,and antiviral treatment should be carried out as soon as possible.