Diagnostic value of 8 serological diagnostic models for the diagnosis of hepatic fibrosis in CHB patients under 30 years of age with normal ALT levels
XUE Qin
LI Yuanyuan
LIN Fengyi
ZHANG Chao
Abstract：Objective To compare the diagnostic efficacy of eight serological diagnostic models for the staging of liver fibrosis in chronic hepatitis B(CHB)patients with normal ALT aged≤30 years,and to select a more convenient and effective diagnostic prediction model to provide early antiviral treatment for this population.Methods A total of 104 CHB patients with normal ALT aged≤30 years who underwent hepatic puncture biopsy at the North Campus of Fifth Medical Center of Chinese PLA General Hospital from January 2015 to December 2020 were selected,evaluating the value of each model for the diagnosis of hepatic fibrosis staging by using the subject operating characteristic(ROC)curves of aspartate aminotransferase to platelat ratio index(APRI),fibrosis 4 score(FIB-4),gamma-glutamyltranspeptidase to platelet ratio(GPR),ratio of serum aspartate to alanine aminotransferase(AAR),fibrosis cirrhosis index(FCI),globulin-platelet model(GP),red cell distribution width to platelet ratio(RPR),and S-index models.Results The AUC of diagnosing liver fiber stage≥S1 from high to low was FIB-4,RPR,APRI,S-index,GPR,GP,AAR and FCI.The AUC of diagnosing liver fiber stage≥S2 from high to low was RPR,S-index,GPR,FIB-4,APRI,AAR,FCI and GP.The AUC for the diagnosis of≥S3 liver fibrosis was RPR,S-index,FCI,GPR,FIB-4,GP,APRI and ARR in descending order.Conclusion RPR and S-index have good diagnostic performance for liver fibrosis staging,with RPR having the best diagnostic performance.
Keywords：chronic hepatitis Bliver fibrosis stagingnoninvasive diagnostic modelsliver biopsydiagnostic efficacy
Publication Date：2023-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 392-397 )