Significance of serum cystatin C level for early diagnosis of renal function impairment in patients with HBV-cirrhosis
SHEN Li-jun
CHU Jin-dong
MA Xue-mei
JIN Bo
MA Yu-ming
LI Li
YAN Li-ping
CHI Chun-sheng
BI Qian
LIU Bo
LAI Wen-hui
CHEN Su-ming
WU Qin
YU Xiao-li
LI Han-wei
XIN Shao-jie
Abstract：Objective To explore the clinical significance of serum cystatin C (Cys C) level for the HBV-cirrhosis patients with early renal function impairment. Methods Five hundred and fifty-two patients with HBV-cirrhosis whose serum creatinine level was lower than 1.5 mg/dl, were enrolled from our center from December 2012 to July 2017. Their clinical characteristics were retrospectively analyzed. The ROC curves of serum Cys C level for early diagnosis of renal function impairment were plotted. Results The serum Cys C was positively correlated with model for end-stage liver disease (MELD) score, and negatively correlated with estimated glomerular filtration rate. The serum Cys C, MELD score and age were the independent risk factors of early renal function impairment in patients with HBV-cirrhosis. The cutoff value of serum Cys C level for the early diagnosis of renal function impairment in patients with HBV-cirrhosis was 1.16 mg/L. Conclusions The serum Cys C level can be an effective marker for early diagnosis of renal function impairment in patients with either compensated or decompensated HBV-cirrhosis.
Keywords：hepatitis BcirrhosisCys Crenal function impairment
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 443-448,478 )