Influence of different types of Helicobacter pylori infection on the levels of serum interleukin-10, interleukin-17 and tumor necrosis factor-α in patients with peptic ulcer
GONG Hui-jie
ZHANG Yi-qiang
LI Dong-fang
Abstract：Objective To explore the influence and significance of different types of Helicobacter pylori (HP) infection on the expression of serum IL-10, IL-17 and TNF-α in patients with peptic ulcer. Methods One hundred and fifty-eight patients with peptic ulcer were included in this study. Among them, 109 cases were positive for HP including 58 cases of HP type I group and 51 cases of HP type II group, and 49 cases were negative for HP. The levels of IL-10, IL-17 and TNF-α in different types of HP infection group were observed. The serum levels of IL-10, IL-17 and TNF-α in patients with gastric ulcer and with duodenal ulcer were compared. Results The levels of IL-10, IL-17 and TNF-α in HP type I group and HP type II group were higher than those in HP negative group (P＜0.05). The levels of IL-10, IL-17 and TNF-α in HP type I group were also higher than those in HP type II group (P＜0.05). In patients infected with HP type I, serum levels of IL-10, IL-17 and TNF-α in duodenal ulcer cases were significantly higher than those in gastric ulcer cases (P＜0.05). There were no significant differences in the levels of IL-10 and TNF-α between gastric ulcer cases and duodenal ulcer cases (P＞0.05); Serum IL-17 level of duodenal ulcer patients was higher than that of gastric ulcer patients, and the difference was statistically significant (P ＜ 0.05). There were no significant differences in serum IL-10, IL-17 and TNF-α levels in HP negative patients with gastric ulcer or duodenal ulcer (P＞0.05). Conclusions The serum levels of IL-10, IL-17 and TNF-α in peptic ulcer patients with different types of HP infection are significantly different and can be used as an important basis for clinical diagnosis.
Keywords：Helicobacter pyloripeptic ulcerIL-10IL-17TNF-α
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 264-266,270 )