Fungal flora distribution and characteristics of T lymphocytes and cytokines level change in patients with mycotic vaginitis

LEI Fang; SONG Ling

doi:10.3969/j.issn.1007-8134.2018.03.015

Abstract：Objective To investigate the distribution and significance of bacterial flora, T lymphocyte and cytokines in the patients with mycotic vaginitis. Methods A total of 182 mycotic vaginitis patients were selected from January to December 2017 in our hospital as observation group, meanwhile 110 healthy volunteers were selected as control group. The levels of T lymphocytes and cytokines in vaginal secretions of all subjects were detected, and fungal culture of vaginal secretions in the observation group was performed. Results Among the involved 182 patients, the pathogenic bacteria were mainly Candida albicans, accounting for 43.41%; The levels of CD3+, CD4+and CD8+T lymphocytes in vaginal secretion of observation group were (52.12±10.45)%, (33.30±8.23)% and (25.10±9.22%), which were significantly lower than those in the control group (P＜0.05); The IL-2, TNF-α and INF-γ in vaginal secretion of observation group were (7.21±1.42) pg/ml, (17.90±4.55) pg/ml and (19.81±4.50) pg/ml, which were significantly lower than those in the control group (P ＜ 0.05), and IL-4 and L-10 levels were (40.32±8.33) pg/ml and (25.66±4.33) pg/ml, which were significantly higher than the control group (P ＜ 0.05); The levels of CD3+, CD4+, CD8+T lymphocytes, IL-2, TNF-α and INF-γ in vaginal secretion of the complicated mycotic vaginitis patients were significantly lower than those of the normal mycotic vaginitis patients (P ＜ 0.05), while IL-4 and IL-10 leves were significantly higher than those of the common mycotic vaginitis patients (P ＜ 0.05). Conclusions Candida albicans is the main pathogen of mycotic vaginitis, and cellular immunity mediated by Th1/Th2 cells is involved in the disease process.