Analysis of drug resistance and influencing factors of pulmonary tuberculosis

XU Li-juan; LIU Hua

doi:10.3969/j.issn.1007-8134.2018.03.014

Abstract：Objective To explore the drug resistance and influencing factors of pulmonary tuberculosis and provide the basis for the formulation of prevention and control measures for tuberculosis. Methods A total of 320 sputum smear positive patients who were treated in our hospital from January 2017 to December 2017 were selected, and the sensitivity of first-line anti-tuberculosis drugs of sputum smear positive patients was detected by proportion method. Meanwhile, general data of the patients including gender and age were collected. Results Among the 320 patients, 56 cases of drug resistance were detected, accounting for drug resistance rate of 17.50%, of which mono-drug resistance rate was 8.13%, poly-drug resistance rate was 2.50%, and multi-drug resistance rate was 6.88%; The rates of retreatment and irregular treatment in drug resistant patients were 62.50% and 66.07%, respectively, which were significantly higher than those of non-drug resistant patients (P ＜ 0.05). There were no significant differences in gender, age, household registration, history of diabetes and history of hypertension between drug resistant patients and non-drug resistant patients (P＞0.05). The results of Logistic regression analysis showed that retreatment and irregular treatment were the risk factors of drug resistance in patients with pulmonary tuberculosis (OR=3.047 and 2.812, P ＜ 0.05). Conclusions Drug resistance is more serious in patients with pulmonary tuberculosis. Retreatment and irregular treatment are risk factors for drug resistance of tuberculosis. Therefore, the prevention and control of tuberculosis should focus on active increase of cure rate of initial treatment, enhancement of health education for patients and improvement of treatment compliance.