Serum levels of TNF-α, IL-6 and IL-8 in hypertensive patients with different types of Helicobacter pylori infection
SUN Ping
SHENG Jia-he
XU Qing-xia
ZHOU Li-li
HONG Xi-tian
Abstract：Objective To investigate the prevalence of Helicobacter pylori (HP) and positive rate of cytotoxin associated protein (CagA) in hypertensive patients and the levels of TNF-α, IL-6 and IL-8 in serum from different types of HP infected patients. Methods Ninety hypertensive patients hospitalized in our hospital (hypertension group) and 65 healthy examinees at the corresponding period (healthy control group) were included in this study. The infection rate of HP and the type of HP were investigated. The serum levels of TNF-α, IL-6 and IL-8 were detected by enzyme linked immunosorbent assay, and the serum levels of TNF-α, IL-6 and IL-8 in patients with different types of HP infection were compared. Results The infection rate of HP in hypertension group was 84.4%, which was significantly higher than that of healthy control group (52.3%), and the positive rate of CagA-IgG in HP infected patients was 80.3%, which was significantly higher than that of healthy controls (58.8%). The difference was statistically significant between 2 groups(P<0.05). The levels of TNF-α, IL-6 and IL-8 in HP-CagA-IgG(+) group were significantly higher than those in HP-CagA-IgG(-) group and HP(-) group, and those in HP-CagA-IgG(-) group were also higher than those in HP(-) group, the differences were statistically significant(P<0.05). Conclusions Hypertension patients have a higher HP infection rate and HP-CagA-IgG(+) positive rate. HP-CagA-IgG positive patients have higher levels of IL-6, IL-88 and TNF-α. Chronic inflammation induced by HP infection may be involved in the pathophysiology of hypertension.
Keywords：hypertensionHelicobacter pylori infectionserum inflammatory factors
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 165-167 )