Expression and significance of long non-coding RNA LOC728290 in tumor tissue of patients with hepatocellular carcinoma
CHENG Si-jie
ZHAO Na-na
YAN Jin
WANG Rui-lan
YU Ling-xiang
XIAO Chao-hui
LEI Guang-lin
ZHANG Pei-rui
WANG Zhao-hai
ZHANG Shao-geng
YANG Peng-hui
Abstract：Objective To determine the expression of long non-coding RNA (LncRNA) LOC728290 in tumor tissue of hepatocellular carcinoma (HCC) patients and explore its clinical significance. Methods The expression level of LncRNA LOC728290 in surgically resected tumor tissues and adjacent non-tumor tissues of HCC patients was detected by using quantitative real-time PCR, and its correlation with clinicopathological characteristics was analyzed. Meanwhile, the correlation between LncRNA LOC72829 expression and recurrence-free survival was analyzed based on the survival period and prognosis follow-up. Results The expression of LncRNA LOC728290 in tumor tissues of 83% (54/65) HCC patients was significantly decreased compared with that in adjacent non-tumor tissues (P < 0.05). A significant difference was observed in LncRNA LOC728290 expression among patients with different levels of serum AFP and patients with or without microvascular invasion (P< 0.05). Survival analysis displayed that the recurrence-free survival rate in patients of lower expression of LncRNA LOC72829 was significantly decreased compared with that of high expression of LncRNA LOC72829 (P<0.05). Conclusions LncRNA LOC72829 is significantly lowly expressed in tumor tissue of HCC patients. It may provide a potential molecular marker and therapeutic target for early clinical diagnosis and evaluating the metastasis and prognosis in HCC.
Keywords：hepatocellular carcinomalong non-coding RNAclinical significance
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 121-124,139 )