Significance of inter-alpha-trypsin inhibitor heavy chain 4 in early warning of virus hepatitis-associated hepatocellular carcinoma
Hu Gao-wa
Li Bo
Xu Fei
Abstract：Objective To investigate the significance of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) for the early warning of hepatocellular carcinoma (HCC). Methods A total of 109 liver cirrhosis patients were followed up, the concentrations of ITIH4 in patients' serum were determined and compared before follow-up and upon the diagnosis. Results After two years of follow-up, 26.6% (29/109) of liver cirrhosis patients developed HCC, serum levels of ITIH4 in HCC patients were significantly lower than those in non-HCC patients (P=0.000). The area under the ROC Curve was 0.667 and the predictive value of ITIH4 was better than AFP. Serum dynamic samples in HCC patients were further detected, and results showed that ITIH4 level of liver cirrhosis patients decreased significantly after developed HCC (P=0.006). Conclusions ITIH4 has early predicting value for HCC progression and can serve as a dynamic monitor. Therefore, this serum marker is better than AFP and has the good application prospect.
Keywords：hepatocellular carcinomaserum tumor markersinter-alpha-trypsin inhibitor heavy chain 4
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 59-62 )