Current status and challenges for diagnosis and treatment of intrahepatic cholangiocarcinoma
ZHANG Ning
LU Shan-shan
Rifaat Safadi
Roberts R Lewis
LU Yin-ying
Abstract：Intrahepatic cholangiocarcinoma (ICC) is a kind of malignant tumor originating from intrahepatic bile duct epithelial cells. Usually it is characterized by insidious attack, being asymptomatic at the early stage and absence of ideal specific biomarkers for the early screening and diagnosis. Many patients have developed into the advanced stage upon diagnosis, thus losing the opportunity of radical resection; the long-time survival prognosis is still poor and the mortality is still high due to tumor recurrence and metastasis even after surgical operation. There is no sophisticated individualized precision strategies for ICC at present. Current staging and prognostic models are mainly established based on the information of patients after resection, which is insufficient in universality and restricts clinical application. Therefore, it is critical to improve the clinical survival outcome through elevating the early diagnostic rate, formulating precise treatment strategy and exploring the prognostic risk factors. We herein reviewe the current status of diagnosis and management as well as the facing challenges based on the research progress of ICC.
Keywords：intrahepatic cholangiocarcinomabiomarkermodelindividualized precision treatment
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 24-30 )