Research progress of drug-resistant tuberculosis
WANG Zhong-yuan
Abstract：Drug-resistant tuberculosis is a severe global public health problem currently, and it influences the control of global tuberculosis epidemics. In addition to known multi-drug resistant tuberculosis, the definitions and types of drug-resistant tuberculosis have been increased recently, such as super extensively drug-resistant the definitions and totally drug-resistant tuberculosis. For the diagnosis of drug-resistant tuberculosis, many methods such as regular bacteriology and nucleic acid analysis are used. Some drug-sensitive cases are limited in the therapy and show an incurable result just because of unbearable to anti-tuberculosis drugs. We name this phenomenon as "clinical resistance". The prevention of drug-resistant tuberculosis depends on individualized chemotherapy with first-line anti-tuberculosis drugs, and the core drugs including isoniazide and rifampicin will play a key role. Though novel anti-tuberculosis drugs will help controlling the multi-drug resistant tuberculosis, comprehensive treatment therapy and local high-dose injection of anti-tuberculosis drugs should still be better methods. Depending on the currently available drugs, individualized treatment of multi-drug resistant tuberculosis is a potential better methods.
Keywords：tuberculosisdrug-resistancediagnosistherapy
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 19-23 )