Application of metagenomic sequencing in detecting the pathogens of infectious diseases
LI Lin-hai
CHEN Li-dan
XIAO Bin
SUN Zhao-hui
Abstract：The infectious diseases are diversiform in clinical manifestation due to the complex pathogenic factors. A rapid, comprehensive and accurate approach to identify pathogenic agents is the prerequisite for clinicians to take active treatment timely and specifically. However, traditional diagnostic methods are limited in detecting small range, time-consuming and complicated operations, which are not suitable for the treatment of infectious diseases at present. The metagenomic sequencing technology is applied to obtain the whole genome sequence of a pathogen without pathogen culture and directly detect the pathogen that causes the infectious diseases. The metagenomic sequencing is a valuable approach in detecting rare infectious diseases. In this study, we review the latest research progress and application of metagenomic sequencing in detecting the pathogens of infectious diseases.
Keywords：high-throughput sequencingmetagenomic sequencinginfectious diseasespathogen
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 15-18 )