Research advance in the strategies for the eradication of HIV reservoir
ZHANG He-qian
CHANG Wen-xian
JIAO Yan-mei
ZHANG Ji-yuan
WANG Fu-sheng
Abstract：The persistence of HIV reservoir is an important cause of persistent infection and difficult to cure in HIV patients. It is difficult to completely remove the viral reservoir with HAART at present. Studies have confirmed that HIV reservoir exists in various types of CD4+ T cells, including central memory CD4+ T cells, CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T cells, stem cell like memory CD4+ T cells, Vγ9Vδ2 T cells and recently confirmed Tfh cells. In addition, studies have also found that macrophages and B cells also couple with viral reservoir. Currently, HIV reservoir eradication strategies mainly include CCR5 gene defective hematopoietic stem cell transplantation, gene editing and activation then killing. These methods still can not effectively remove HIV reservoir. Recent studies have shown the specifically high expression of CD32a molecules on the surface of HIV latent CD4+ T cells, which provides new marker for the elimination of viral reservoir. We review the possible immunocytes with HIV reservoir and the research progress on the eradication strategies of HIV reservoir.
Keywords：HIV reservoirsimmunocyteseradication strategies
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 321-326 )