Surveillance and analysis of bacterial resistance in a general hospital from 2014 to 2016

DENG Ming-qiong; YU Hai-xia; YANG Hong

doi:10.3969/j.issn.1007-8134.2017.05.014

Abstract：Objective To summarize the distribution characteristics of pathogens and resistance in Ganzi Tibetan Autonomous Prefecture People's Hospital from January 2014 to December 2016, and provide reference for the reasonable use of antibacterial drugs.Methods The pathogen specimens collected from the wards of Ganzi Tibetan Autonomous Prefecture People's Hospital from January 2014 to December 2016 were analyzed retrospectively. VITEK2-compact15 automatic microbial identification drug susceptibility analysis system was used for bacterial identification and drug susceptibility testing. The drug susceptibility testing results were analyzed according to the antimicrobial drug susceptibility point standard of drug sensitivity standard in 2015 formulated by American Clinical and Laboratory Standardization Association (CLSI M100-S25 version). WHONET 5.6 software was used for data statistics and analysis.Results A total of 33516 clinical specimens were collected from January 2014 to December 2016, among which 2987 bacteria were isolated with the positive rate of 8.91%. The isolates were mainly gram-negative bacilli, and Escherichia coli was the first followed by Klebsiella pneumoniae. Pathogens mainly came from sputum, urine, pus, incision secretions, blood, vaginal secretions, bile, ear vein secretions and other specimens. The first three departments of the specimens sent to detect were the surgery, internal medicine and ICU. The resistance rates of Escherichia coli towards ampicillin, ampicillin/sulbactam, ceftriaxone and compound sulfamethoxazole were 88.04%, 53.30%, 50.75% and 43.69%, respectively. Except ampicillin, the resistance rates of Klebsiella pneumoniae towards common antibiotics were less than 40%. The resistance rates of Escherichia coli towards ampicillin, Staphylococcus aureus towards penicillin, Acinetobacter baumannii towards cefotetan, aztreonam and ampicillin were no less than 75%. The total detection rates of methicillin resistant staphylococcus aureus and methicillin-resistant staphylococcus epidermidis were decreasing from 2014 to 2016. Conclusions The bacterial resistance becomes more serious, especially the multidrug resistance detection rate of important pathogens is increasing. Therefore, the change of pathogens and drug resistance should be monitored in time. Antibacterial agents should be selected rationally for different drug resistance conditions. The hospital prevention and control work should be done well for multidrug resistant bacteria.