Influence of bile acid metabolism changes on pathogenesis of hepatocellular carcinoma
ZHANG Ting
DONG Jin-ke
YANG Xin-rui
DU Gui-fang
LI Yin-yin
LU Shan-shan
LU Yin-ying
QU Jian-hui
ZENG Zhen
Abstract：Objective To investigate the changes of serum bile acids (BAs) concentration and components in patients with HBV related hepatocellur carcinoma (HCC), and explore the relationship between BAs and HCC. Methods Liquid chromatography mass spectrometry was used to detect the concentration of serum BAs in 24 HCC patients, 15 HBV related liver cirrhosis patients, 6 chronic HBV hepatitis patients and 12 healthy controls. The expression levels of IL-1β in liver tissues and paracancer tissue were detected by real-time PCR and immunohistochemistry in 15 liver cirrhosis cases. Results The cholic acid, chenodeoxycholic acid, tauro ursodesoxy cholic acid, lithocholic acid, glycochenodeoxycholic acid, glycochenodeoxycholic acid concentrations were significantly higher in 24 HCC patients than those in the heath control and liver cirrhosis group (P < 0.05). The concentrations of lithocholic acid (LCA) were positively correlated with the clinical stage of HCC and showed significant differences in different stages, the concentration at stage C was obviously higher than that at stage B and stage A. The expression level of IL-1β in cancer tissues was lower than that in adjacent tissues.Conclusions The increase of plasma bile acid LCA is correlated with the development of liver cancer. It may be an evaluation index for the progress of HCC.
Keywords：hepatitis B virus related hepatocellular carcinomabile acidIL-1βtargeted metabolomics
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 293-297 )