Drug resistance analysis of extended-spectrum β-lactamase-producing E. coli causing urinary tract infections
ZHAO Wen-shen
CHEN Hui-xia
LI Shou-xia
Abstract：Objective To investigate the drug resistance of extended-spectrum β-lactamase (ESBLs)-producing E. coli isolated from patients with urinary tract infections and provide guidance for rational use of antibiotics. Methods All E. coli strains were isolated from patients with urinary tract infection in our hospital from January 2015 to January 2016. Bacterial identification was used with VITEK2 bioMerieux (France). The conformation of ESBLs and drug resistance were detected with Kirby-Bauer method.Results A total of 432 E. coli strains were isolated from patients with urinary tract infections, 226 isolates produced ESBLs, the detection rate was 52.31%. The drug sensitivity analysis showed resistant rate of meropenem to ESBLs producing strains was only 0.88%, then nitrofurantoin with 19.91%, and the highest ampicillin was 98.23%. In addition, the resistant rates for antibiotics containing enzyme inhibitors were also significantly higher. Compared with the non ESBLs producing strains, the resistant rates of the ESBLs producing strains were significantly increased. Conclusions For the high prevalence of ESBL-producing E. coli isolated from patients with urinary tract infections, the detection and surveillance of ESBLs for E. coli are essentially important for initiate appropriate therapies in clinical practice, infection control and epidemiological surveillance.
Keywords：urinary infectionE. coliextended-spectrum β-lactamasesantibiotic resistance
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 269-271 )