Study on the expressions of hepatocyte growth factor activator inhibitor -1, -2 after partial hepatectomy in rats
XI Rui
LI Xiao-tao
WANG Lu
WANG Li-juan
Abstract：Objective To investigate the expressions of hepatocyte growth factor activator inhibitor (HAI-1 and HAI-2) expression after partial hepatectomy, to analyze the functions of HAI-1 and HAI-2 in liver regeneration. Methods Sixty healthy male SD rats were randomly divided into control group and hepatectomy group. Before operation and at 3 h, 12 h, 24 h and 48 h after operation, the expressions of HAI-1, HAI-2 mRNA and protein in the 2 groups were compared. Results Before operation, HAI-1, HAI-2 mRNA and protein expression levels were significantly low in the 2 groups, there were no significant differences between 2 groups (P>0.05);When compared with the data before operation, there were no obvious changes on the HAI-1, HAI-2 mRNA and protein expressions of the control group (P > 0.05). However, the levels of HAI-1 mRNA and protein expression increased at first and then decreased gradually in the hepatectomy group after operation. When compared with the control group at the same time point, the difference was statistically significant (P < 0.05), but there were no significant changes in HAI-2 mRNA and protein (P > 0.05). Conclusions HAI-1 is highly expressed in the regeneration process after partial hepatectomy, it may be involved in the process of hepatocyte regeneration. But HAI-2 has no significant effect on liver regeneration.
Keywords：liver resectionliver regenerationHAI
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 161-163,171 )