Characteristics and rescue therapy strategies of multidrug-resistant HBV infection
ZHOU Yi
LIU Yan
XU Dong-ping
LIU Min
Abstract：Multidrug-resistant HBV infection is a great challenge to the antiviral therapy in clinic. The development of multidrug-resistant HBV is associated with virus factors, host factors and drug factors. Strict evaluation on the treatment indications, choosing nucleos(t)ide analogues with a higher drug-resistant genetic barrier in initial treatment regimen and avoiding sequential mono- therapy starting with a lower drug-resistant genetic barrier drug can reduce the risk of developing multidrug-resistant HBV strain. Rescue therapy should be taken as early as possible for patients who have already developed the drug-resistant and multidrug-resistant virus infection. Recently, increasing evidence suggest that combination of entecavir and tenofovir is a more efficacious and safer rescue therapy for difficult-to-treat multidrug-resistant HBV infection. The development of new antiviral agents with multiple-targets may provide a new way for the treatment of multidrug-resistant HBV infection.
Keywords：hepatitis B virusmultidrug-resistanceantiviral agentsrescue therapy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 109-114 )