Establishment and application of human liver chimeric mouse models in HBV-induced pathogenesis
FU Zhong-xing
YANG Fan
WANG Ling
ZHANG Hong-wei
CAO Guang-wen
Abstract：Viral hepatitis, especially hepatitis B, has long been heavy burden of liver disease worldwide. However, due to its host spectrum exclusively being primates, HBV infection is hard to be replicated in animal models. Human liver chimeric mouse models are generated from immunodeficient and liver defected mice transplanted with human hepatocytes. Due to chimerism with human hepatocytes, the mouse models can be infected by HBV and liver disease models can be generated. The mechanism by which HBV causes liver diseases can be elucidated accordingly. The models are constructed mainly on the basis of Alb-uPA mouse model and Fah-/- mouse model. HBV can be detected both in the human chimeric liver tissue and peripheral blood of the models. The models have been applied for the investigation of HBV mutations, HBV gene functions, anti-HBV agent effects, the interactions between HBV and immune system. This article reviews the advantages and disadvantages of those HBV infection models and emphasizes the advances and improvement in human liver chimeric mouse models.
Keywords：mouse modelshepatitis B virusimmunodeficiency micehumanized micehuman liver chimeric mouse model
Publication Date：2017-03-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 75-81 )