Analysis on the normalization rate of thrombocyte counts and related factors in HIV/AIDS patients with thrombocytopenia after HAART

DAI Guo-rui; CHONG Xue-jing; XIAO Jiang; XU Ling; WANG Di; HAO Yu; ZHAO Hong-xin

doi:10.3969/j.issn.1007-8134.2017.01.010

Abstract：Objective To analyze the normalization characteristics of thrombocyte on HIV/AIDS patients with thrombocytopenia after the HAART given to them, and to investigate the influence factors.Methods Total of 132 HIV/AIDS patients with thrombocytopenia hospitalized in Ditan hospital from June 2003 to December 2015 were treated by HAART. The normalization rate of thrombocyte and its characteristics were analyzed retrospectively on the time of 4 weeks and 24 weeks after the HARRT. Results Among 132 patients, 99 (75.00%) were mild thrombocytopenia, and 19 (14.39%) and 14 (10.61%) were moderate and sever thrombocytopenia, respectively. The normalization rate of platelet was 63.9% and 80.8% respectively after the patients having received HAART for 4 weeks and 24 weeks. The difference was statistically significant (P=0.003). Univariate logistic regression analysis suggested that the transmission via blood(OR=4.632,P=0.024), HBsAg positive(OR=3.829,P=0.024) and anti-HCV positive(OR=6.476,P=0.020) were related factors of the normalization of PLT. Multivariate logistic regression analysis suggested that HBsAg positive(OR=4.345, P=0.027) influenced the normalization of PLT.Conclusions HARRT is the most effective treatment to the HIV/AIDS patients with thrombocytopenia, and the timely initiation of HAART can avoid the continuous decrease of thrombocyte. HBsAg positive is the main factor to affect the normalization of PLT. Adequate attention should be given to the patients with risk factors, and intervention should be implemented in time.