Study on the mechanism of granulocyte colony-stimulating factor in the treatment of liver failure
HU Jin-hua
Abstract：The clinical medical treatment of liver failure is lack of effects of drugs. Recent reports of granulocyte colony-stimulating factor (G-CSF) can be effective in the treatment of liver failure induced by alcoholic hepatitis and hepatitis B virus (HBV), and improve the survival rate of patients. The study of related therapeutic mechanism showed that G-CSF could mobilize bone marrow hematopoietic stem cells (HSCs). Among them, on one hand, HSCs is directly differentiated into hepatocytes; on the other hand, HSCs may change the microenvironment of the liver by paracrine secretion, enhance endogenous hepatic oval cells proliferation and initiate endogenous repair procedures involved in liver tissue repair. G-CSF may also play a role in protecting the liver by inhibiting apoptosis / necrosis and regulating immune. At the same time, it is necessary to carry out a multicenter randomized controlled clinical trial of the therapeutic effects and safety of G-CSF for the treatment of liver failure, and to provide a high level basis of evidence-based medicine for the application of G-CSF.
Keywords：liver failureG-CSFapoptosisimmune regulationtherapiesinvestigational
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 375-377 )