Advances in the correlation between TRAIL and its receptors and HBV-related chronic liver disease
LI Chen
WAN Zhi-hong
XIN Shao-jie
Abstract：Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) belongs to the tumor necrosis factor (TNF) superfamily. After TRAIL bound to death receptor, waterfall-like cascade reaction of caspase can be activated. Tumor cells, transformed cells and virus-infected cells can be induced to undergo apoptosis by this reaction, but it has not produce apoptosis function in normal tissues and cells. By interacting with hepatitis B virus (HBV), cytokines and other factors, TRAIL and its receptors play an important role in the pathogenesis of HBV-related chronic liver disease. In addition, it has a correlation between TRAIL expressionin vivo and chronic hepatitis B (CHB) patients with antiviral treatment. This review focuses on the correlation between TRAIL and its receptors and HBV-related chronic liver disease, and provides a theoretical basis for their relationship.
Keywords：TRAILHBVchronic liver disease
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 370-374 )