The effect of 2 different doses of gamma globulin in the treatment of severe hand-foot-mouth disease
GUAN Sheng-can
WANG Yu-hai
HUANG Wei
LIU Lu
LI Qin
Abstract：ObjectiveTo observe the therapeutic effects of two groups of gamma globulin with various doses on severe hand-foot-mouth disease (HFMD).MethodsIn total of487 cases of patients with HFMD were selected and were divided into full dose of intravenous gamma globulin group (n=313, the full dose group) and half dose of intravenous gamma globulin group (n=174, the half dose group), and the two groups were given treatment in accordance with treatment principles of severe illness in theDiagnosis and Treatment Guidelines for Hand-foot-mouth Disease (2013). The defervescence, other symptoms, adverse reaction, average length of stay and average hospitalization expenses were observed.ResultsThe treatment results indicated that the full dose group and the half dose group showed no statistically significant differences in therapeutic effects of defervescenceand deflorescence, as well as the average length of stay; while the difference in the average hospitalization expenses of the two groups showed statistical significance, with those in the full dose group being remarkably higher than those in the half dose group (P=0.008).ConclusionsIn the case of treating patients with severe HFMD in clinic, half dose of gamma globulin can reduce the expenses of patients, alleviate economic burden, and have comparable therapeutic effects with the full dose of gamma globulin in terms of length of stay and defervescence, thus it is worthy of being promoted in clinic.
Keywords：severe hand-foot-mouth diseasegamma globulinclinical research
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 363-365 )