Analysis on incidence and risk factors of first-line treatment failure among HIV/AIDS patients
CHONG Xue-jing
DAI Guo-rui
WANG Di
XU Ling
HAO Yu
ZHAO Hong-Xin
Abstract：ObjectiveTo analyze the incidence and risk factors of first-line treatment failure among HIV/AIDS patients who received first-line highly active antiretroviral treatment (HAART). The outcomes of the study aim to provide early warnings to treatment failure and improve the HIV treatment efficacy.MethodsThe evaluation of basic demographic information, baseline characteristics, incidence, and risk factors of treatment failure was conducted retrospectively in HIV/AIDS patients who received free first-line HAART in Beijing Ditan Hospital from 2005 to 2015.ResultsOverall incidence of first-line was 3.39% in our cohort. Blood transmission (OR=3.713), baseline CD4 counts<200 cells/μl(OR=2.167), baseline VL≥5logcopies/ml(OR=2.137), combined with the opportunistic infections(OR=3.476) were risk factors of first regimen failure. Treatment failure was not associated with gender, age, baseline HBV/HCV co-infection and the interval from the confirmation to initial treatment. ConclusionsFirst-line failure was associated with blood transmission, lower baseline CD4 counts, baseline opportunistic infection and higher baseline VL. Adequate attention involving better treatment regimen options and notice of drug interaction is needed to ensure optimal treatment outcomes among HIV/AIDS patients, especially ones with these risk factors.
Keywords：HIV/AIDSHAARTfirst regimen failurerisk factors
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 340-344 )