Techniques for HBV drug-resistant mutation detection during antiviral therapy
ZHANG Shu-yong
CHEN Chen
MA Qing-wei
QU Fen
Abstract：China is a country with high incidence of hepatitis B (HBV). The early detection of antiviral drug resistance mutations in patients with hepatitis B is essential for the treatment of hepatitis B patients. Theoretically, the ideal clinical detection method should be with high sensitivity and high specificity, good repeatability, accurate detection results and also has the advantages of simple operation, high flux, moderate price, available quantitative detection, and can detect a variety of mixed mutations in samples. In this paper, based on the above clinical requirements, the authors have discussed the detection technology of hepatitis B drug-resistance mutations in recent years, and introduced a new detection technology based on matrix-assisted laser desorption /ionization time- of -flight mass spectrometry(MALDI-TOF MS).
Keywords：HBVdrug-resistant genetic variationMALDI-TOF MS
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 311-314 )