Advances in animal models of HBV infection and replication
YANG Yue
XU Zhi-hui
LIU Yan
XU Dong-ping
Abstract：HBV infection animal model is an essential tool for studying pathogenesis of HBV and screening novel and effective anti-HBV drugs or treatment methods. However, HBV infection is highly tissue specific and species-specific, which brings difficulties to the establishment of HBV infection model. In recent years, with advances in technology of related disciplines such as molecular biology, experimental zoology, virology, and immunology, obvious progress has been acquired in HBV infection or replication animal models. Currently-used HBV animal models (including those models for animal hepatitis with similar characteristics of HBV) are mainly comprised of chimpanzee, tree shrew, woodchuck, and duck viral infection model, HBV transgenic mouse, hydrodynamic injection of HBV vector, and adeno-associated virus-mediated mouse HBV replication models, as well as human-murine liver chimeric mouse HBV infection model. In addition, sodium-taurocholate co-transporter transgenic mouse model is a hotspot in recent years. This article provides an overview of advances in above-mentioned HBV animal models.
Keywords：hepatitis B virushepatitis Bmodelsanimalsinfection
Publication Date：2016-07-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 236-241 )