Early diagnosis of tuberculosis meningitis
JU Li-zhong
WU Cheng
HUANG Zhi-cheng
LIU Guo-cai
LIU Yu-qiang
Abstract：ObjectivesTo investigate methods for early diagnosis of tuberculous meningitis (TBM) by comparing the clinical and laboratory features of TBM and acute bacterial meningitis (ABM).MethodsThe clinical and laboratory data of 178 TBM patients and 87 of ABM patients, who were hospitalized from January 2005 to May 2014, were retrospectively analyzed. Logistic analysis was applied to screen the factors related to the diagnosis, and ROC curve was applied to explore the cutoff value. Then an early diagnosis model for TBM was developed.ResultsFactors related to the early diagnosis of TBM included headache duration≥6 days, peripheral blood WBC count<14×109 /L, CSF WBC count<600×106 /L and CSF neutrophil percentage<0.75. The AUC of the early diagnosis model developed based on the 4 factors was 0.999 (95%CI: 0.998-1.000), with a high diagnosis value. The misjudgment rate of this early diagnosis model was 1.15%, lower than that of Thwaites’ model (8.85%).ConclusionsThe model developed for the early diagnosis of TBM has a high diagnosis value with a high diagnosis coincidence rate. It’s worthy of further clinical verification and application.
Keywords：tuberculosismeningealcranial nerve diseasescerebrospinal fluidearly diagnosis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 148-152 )