Efficacy of amphotericin B, fluconazole and itraconazole in treatment of AIDS complicated by penicilliosis marneffei: a meta-analysis
CHEN Yue-hua
LIN Yan-rong
LIU Sheng
Abstract：Objective To evaluate the efficacy of amphotericin B, fluconazole and itraconazole in treatment of AIDS complicated by penicilliosis marneffei (PSM) with meta-analysis.Methods Cochrane Library, PubMed, Ovid database, Embase database, Wanfang database, National Knowledge Infrastructure full-text database and China BioMedical Literature database were searched. Literatures were selected according to the criteria recommended by Cochrane Method Group and evaluated according to the quality. Meta-analysis was performed with Stata version 12.0.Results Six papers were identified, in which a total of 893 AIDS patients with PSM were recruited, 467 patients receiving amphotericin B, 152 patients fluconazole and 274 patients itraconazole. Meta-analysis showed that patients receiving amphotericin B had a higher recovery rate [OR=7.138 (95%CI 1.761-28.932),P<0.05] and a lower mortality rate [OR=0.507 (95%CI0.294-0.875),P<0.05] than patients receiving fluconazole, and the differences between the two patient groups were significant. The recovery rate [OR=0.777 (95%CI 0.498-1.212),P>0.05] and mortality rate [OR=1.427 (95%CI 0.890-2.287),P>0.05] were not significantly different between patients receiving amphotericin B and those receiving itraconazole.Conclusions Amphotericin B has a better efficacy in treatment of AIDS complicated by PSM than fluconazole, and the treatment efficacy is not significantly different between amphotericin B and itraconazole. More prospective data need to be accumulated for further verification.
Keywords：acquired immunodeficiency syndromepenicilliumamphotericin Bfluconazoleitraconazolemeta-analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 101-105,128 )