Effect of delivery modes on blocking mother-to-child transmission of HBV in HBV-infected mothers with high viral load
ZHOU Ming-fang
LIU Min
YI Wei
CAI Hao-dong
Abstract：Objective To investigate the effect of delivery modes on blocking mother-to-child transmission of HBV in HBV-infected mothers with high viral load.Methods A total of 570 pregnant women with HBV DNA levels≥1×106 copies/ml, who delivered their babies at our hospital from January 1, 2012 to December 31, 2014, were selected. Their delivery modes were analyzed, and HBV serological markers at neonatal birth and after the whole hepatitis B vaccination (7-12 months old) were detected.Results Totally 292 infants (3 pairs of twins) were born to 289 mothers (50.7%) by caesarean section delivery, of whom 270 newborn infants (92.5%) had immune response to hepatitis B vaccine, 3 (1.0%) didn't have immune response, and 19 (6.5%) were infected with HBV. Totally 281 infants were born to 281 mothers (49.3%) by vaginal delivery, of whom 252 newborn infants (89.7%) had immune response to hepatitis B vaccine, 4 (1.4%) didn't have immune response, and 25 (8.9%) were infected with HBV. The failure rate in blocking mother-to-child transmission in the group of vaginal delivery was higher than that in the group of cesarean section delivery, but the difference between them was not significant (8.9%vs 6.5%,χ2=1.153,P=0.283).Conclusions Methods of delivery have no significant effect on HBV transmission through blood from the mother to the baby, thus having no significant effect on blocking mother-to-child transmission.
Keywords：hepatitis B virushepatitis B vaccinesmaternal-fetal exchange
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 85-88 )