Efficacy and safety of the use of cycloserine in treatment of multi-drug resistant tuberculosis
PEI Jie
YIN Chun-lian
QIN Wei
SU Guo-sheng
Abstract：Objective To investigate the efficacy and safety of the combination use of cycloserine and anti-tuberculosis (TB) drugs for multi-drug resistant TB (MDR-TB). Methods A total of 98 patients treated in Fourth People's Hospital of Nanning, who wereenrolled in the global round 5 MDR-TB fund project, were selected. All the patients were divided into 2 groups, an experimental group (n=50) and a control group (n=48). Based on standard MDR-TB treatment, the experimental group was given cycloserine and the control group para-aminosalicylic acid additionally. The therapeutic efficacy and adverse reactions of the 2 groups were com-pared. Results The sputum negative conversion rates at months 3, 6, 9, 12, and 24 of treatment were not significantly different be-tween the experimental group and the control group (P>0.05). The occurrence of adverse reactions in central nerve system and peripheral neuropathy in the experimental group was significantly higher than that in the control group, while the occurrence of adverse reactions in gastrointestinal tract and drug-induced liver injury in the control group was significantly higher than that in the experimental group (P<0.01). Conclusions Cycloserine and para-aminosalicylic acid are equally effective in treatment of MDR-TB. However, they may cause adverse reactions, which should be studied deeply.
Keywords：tuberculosispulmonaryantitubercular agentscycloserinetreatment outcome
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 237-240 )