Multiple organ injury of severe fever with thrombocytopenia syndrome
ZHANG Wen-li
SONG Rui
SHEN Yi
ZHAO Yong-xiang
YU Xiao-li
GUO Li-na
TIAN Di
FU Xiao-kang
ZHANG Wei
GUAN Xiao-qing
CHEN Zhi-hai
Abstract：Objective To investigate the characteristics and regularity of development of multiple organ injury in patients with severe fever with thrombocytopenia syndrome (SFTS). Methods Clinical and laboratory data of 68 SFTS patients were collected. Signs, symptoms and biochemical indicators of the liver injury, heart injury, blood system injury, kidney injury, brain injury and other organ injury were dynamically analyzed. Results Liver injury was found in 66 SFTS patients (97.06%). In the early, critical and recovery stages of SFTS, the quartiles of ALT were 76.6 (44.1, 126.0) U/L, 131.1 (73.0, 219.5) U/L and 120.6 (74.3, 199.0) U/L, respectively;the quartiles of AST were 164.6 (92.3, 283.6)U/L, 249.5 (107.5, 426.0) U/L and 101.3 (49.0, 188.0) U/L, respectively. Compared with other myocardial enzyme indicators, LDH and α-HBDH increased more obviously. In the early, critical and recovery stages of SFTS, the quartiles of LDH were 677.5 (389.0, 1 412.5) U/L, 922.0 (618.0, 1 804.5) U/L and 470.0 (306.0, 733.0) U/L, respectively;the quartiles ofα-HBDH were 398.5 (196.3, 662.3) U/L, 584.0 (372.5, 895.0) U/L and 317.0 (226.0, 478.0) U/L, respectively. CKMB basically re-mained normal. WBC and PLT decreased in 67.65%and 100%of the patients, respectively. In the early, critical and recovery stages of SFTS, the quartiles of WBC were 2.56 (1.00, 6.40)×109/L, 3.14(1.93, 7.16)×109/L and 4.22 (3.11, 6.34)×109/L, respectively;the quar-tiles of PLT were 40.7 (23.3, 53.3)×109/L, 40.0 (25.2, 51.3)×109/L and 123.0 (58.0, 218.8)×109/L, respectively. Twenty-seven patients had positive tests for urinary occult blood, and 45 patients for urinary protein. But creatinine and urea nitrogen of the most patients re-mained normal. Eleven patients had abnormal consciousness, and 5 patients had pathological reflex. Four patients (5.88%) died, with multiple organ failure as the cause of death. Conclusions The injuries to liver, heart, kidney, blood system and other organs are the important clinical features of SFTS. The injury begins at the early stage of the disease, becomes the most severe in the critical stage, alleviates and recovers gradually in the recovery stage. A small number of patients die of multiple organ failure.
Keywords：thrombocytopeniafeverBunyaviridae infectionsmultiple organ failure
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 234-237 )