Predictive value of interleukin-32 and matrix metalloproteinases-2 in peripheral blood for the prognosis of HBV-related acute-on-chronic liver failure
CAO Li
WANG Mei-hua
ZOU Mei-yin
ZHU Yong-gen
Abstract：Objective To investigate the predictive value of the levels of interleukin ( IL )-32 and matrix metalloproteases (MMP)-2 in peripheral blood for the prognosis of patients with HBV-related acute-on-chronic liver failure (HBV-ACLF). Methods To-tally 34 HBV-ACLF patients and 31 patients with chronic hepatitis B (CHB) were enrolled in the study. The levels of IL-32 and MMP-2 in peripheral blood were detected by ELISA. The relationships between IL-32, MMP-2 and ALT, AST, TBIL, ALB, PT were analyzed. The logistic binary regression was used to analyze the predictive value of the levels of IL-32 and MMP-2 for the prognosis of HBV-ACLF. Results In HBV-ACLF group, IL-32 had a moderately positive correlation with TBIL and PT (rs=0.774,0.686), and a weakly negative correlation with ALB (rs=-0.456);MMP-2 and ALB were weakly negatively correlated (rs=-0.451);IL-32 and MMP-2 were weakly positively correlated (rs=0.580). In CHB group, IL-32 was weakly positively correlated with TBIL and PT (rs=0.439, 0.555);MMP-2 was weakly positively correlated with AST(rs=0.417), weakly negatively correlated with ALB(rs=-0.541), and moderately posi-tively correlated with TBIL and PT(rs=0.647, 0.766);IL-32 and MMP-2 were weakly positively correlated(rs=0.590). The level of IL-32 in peripheral blood increased in turn in HBV-ACLF group, CHB group and control group (P<0.05). The level of MMP-2 in HBV-ACLF group was significantly higher than that in CHB group and control group (P<0.05), but the level was not significantly differ-ent between CHB group and control group. Compared with CHB group, the occurrence of co-infection was more frequent, and the levels of MMP-2 and IL-32 were higher in HBV-ACLF group. Logisitic regression analysis showed that IL-32 was closely correlated with the prognosis of ACLF. Conclusions The levels of IL-32 and MMP-2 in peripheral blood can reflect the degree of liver injury. IL-32 is closely correlated with the prognosis of HBV-ACLF.
Keywords：hepatitis Bchronicacute-on-chronic liver failureinterleukin-32matrix metalloproteinase-2
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 227-230 )