Clinical analysis of 126 patients with HIV and Mycobacterium tuberculosis coinfection

WU Qiu-yun; LU Xiang-chan; HUANG Ai-chun; XIE Zhi-man; HE Hua-wei; ZHU Qing-dong; SU Qi-si; LI Qing-rong; RUAN Guang-jing; OU Ru-zhi

Abstract：Objective To investigate the therapeutic efficacy on HIV and Mycobacterium tuberculosis ( MTB ) coinfection . Methods The incidence of immune reconstitution inflammatory syndrome (IRIS) and the increased level of CD4+T lymphocyte count were observed within one year after giving highly active antiretroviral therapy (HAART) in 126 patients with HIV/MTB coinfection, so as to analyze the clinical effects. Results All the 126 patients completed TB treatment and within one year after receiving HAART, there were no death and reoccurrence of TB. CD4+T lymphocyte count increased gradually after HAART and increased the most greatly at week 12. During the treatment, IRIS was found in 37 patients (29.37%). The incidence of IRIS in patients with CD4+T lymphocyte count less than 200 cells/mm3 was higher than that in patients with CD4+T lymphocyte count equal to or more than 200 cells/mm3 (χ2=6 . 206 , P=0 . 013 ) . The increases in CD4+ T lymphocyte count at week 12 and 48 in patients with CD4 + T lymphocyte count less than 200 cells/mm3 were less than those in patients with CD4+ T lymphocyte count equal to or more than 200 cells/mm3 (P<0.05). Conclusions The patients with HIV/MTB coinfection who initiate HAART when their CD4+T lymphocyte counts are equal to or more than 200 cells/mm3 have a low incidence of IRIS, showing a good immune reconstitution.