Research advances in immunopathogeneses of Ebola virus
LIU Sai
ZHANG Yong-hong
Abstract：The 2014 West Africa Ebola virus disease outbreak has been recognized as the most severe global public health emergency of the year. With its rapid and intensive outbreak, high mortality and lack of specific treatment and vaccines, widely spread fear has cast the globe with shadow, which requires due attention from the health and medical fields. The main immuno-pathogenesis include excessive secretion of cytokines and chemokines caused by infected mononuclear phagocytic system and dendritic cells, impairment of secretion and response pathway for interferon, and severe apoptosis of a various kinds of immune cells;in-duction of the expressions of some certain kinds of surface molecules, which leads to coagulopathy;multi-organ injuries caused directly by spread and replication of the virus. In this article, research advances in immunopathogeneses of Ebo la virus are discussed by re-viewing previous reports.
Keywords：Ebolavirusimmunityinnateacquired immunityvaccines
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 55-59 )