Clinical analysis of 21 pregnant women with tsutsugamushi disease

ZHANG Guo-li; SU Hui-yong; YANG Lei; YIN Shi-ming

Abstract：Objective To investigate the clinical characteristics of tsutsugamnshi disease in pregnant patients, so as to provide evidence for early diagnosis and treatment. Methods The clinical data, including signs and symptoms, laboratory findings, treatment and outcome of 21 pregnant women with tsutsugamushi disease were analyzed retrospectively. Results The 21 patients with tsutsuga-mushi disease were in middle and late stage of pregnancy. Fever was present in all the patients, eschar in 16 patients, rash in 4 patients, enlarged lymph node in 5 patients and liver and spleen enlargement in 2 patients. The Weil-Felix OXk test was positive in 6 patients. Preterm delivery occurred in 7 patients, and intrauterine demise in 2 patients. The disease was often complicated by liver, kidney, lung and heart injury and other multiple organ injury. All patients were given azithromycin treatment with the curative rate of 100%, and no significant adverse reactions were found. Conclusions The clinical manifestations of pregnant women with tsutsugamushi disease were complex, and the patients often present with multiple organ injury. Azithromycin treatment is safe and effective.