Therapeutic efficacy of 731 naive AIDS patients in Beijing

ZHANG Jing-ji; SONG Jing-jing; LI Zai-cun; GUO Cai-ping; SUN Li-jun; WU Hao; HUANG Xiao-jie

Abstract：Objective To investigate the therapeutic efficacy and drug-related adverse reactions of free antiretroviral treat-ment in naive AIDS patients, so as to provide evidence for the prevention and treatment of AIDS in Beijing. Methods Clinical data of 731 naive AIDS patients receiving antiretroviral therapy in Beijing You'an Hospital from Jan. 2005 to Aug. 2011 were collected, and the therapeutic efficacy and drug-related adverse reactions of the antiretroviral treatment were analyzed. Results The number of the patients with viral load less than 50 copies/ml increased gradually after the start of treatment, accounting for about 80%; viral load decreased and was undetectable in 91.1% of the patients at 18 months of treatment. CD4+T lymphocyte count increased gradu-ally during treatment, and maintained stable after 3 years of treatment. The most common drug-related adverse reactions were gas-trointestinal reactions. The main reason for switching regimens during treatment was drug-related adverse reaction. Conclusions The traditional antiretroviral therapy can achieve good antiviral efficacy, decreasing viral load in plasma and increasing CD4+T lympho-cyte count significantly. The main reason for switching regimens is drug-related adverse reaction.