Prognostic value of common inflammatory markers combining MELD score for chronic severe hepatitis prognosis
YUAN Wen-wen
WANG Han
GENG Wei
ZHU Jian-gong
LI Pei-ran
HE Ye-li
YANG Ning
LI Yan
GUO Tong-sheng
Abstract：Objective To evaluate the prognostic value of procalcitonin (PCT)and common inflammatory markers combining the model for end-stage liver disease (MELD) score in patients with chronic severe hepatitis (CSH). Methods A total of 87 patients with CSH were collected from Jan. 2011 to Dec. 2013. Indexes of PCT, endotoxins, WBC, PMN, C-reactin protein (CRP) and MELD were determined within 24 h after the admission. According to the outcome, the 87 patients were divided into a survival group (n=51) and a death group (n=36). Results PCT, CRP, MELD score and PMN in survival group by single factor analysis were significantly lower than those in the death group (P<0.05). Binary logistic regression analysis indicated that MELD score, CRP and PCT highly correlated with the death of CSH. CRP was positively correlated with MELD score and Spearman's correlation coefficient was 0.69 (P<0.05). PCT was also positively correlated with the MELD, and Spearman's correlation coefficient was 0.72 (P<0.05). Conclusion Compared with the traditional prediction method, serum PCT and CRP can improve the ability to predict the prognosis for CSH.
Keywords：hepatitischroniccalcitoninend stage liver diseaseendotoxins
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 286-288 )