Application of microbial whole-genome sequencing technology in the area of preventive medicine
CUI Yu-jun
YANG Rui-fu
Abstract：When being faced with infectious disease caused by a specific pathogen, several immediate questions need to be addressed to make effective prevention and control strategy. Firstly, where does the pathogen come from, and what is the possible transmission pathway? Secondly, what are the surviving, virulent and antibiotic resistance features of the etiologic agent? Thirdly, what kind of epidemiological pattern of a disease is revealed by the pathogen's genomic analysis? Dramatic development of high-throughput sequencing technology and bioinformatic analysis strategy has provided novel solutions to these questions in recent years. In this review, the authors summarize the successful application cases of the next-generation whole-genome sequencing technology in the area of preventive medicine, including epidemiological investigation for source-tracing, rapid identification of pathogen's fea-tures, epidemiological characteristics of a disease, and surveillance and evaluation of live attenuated vaccine variations, and also dis-cuss the questions presenting in current stage and propose the possible scenario of this research area in the future.
Keywords：genomemicrobiologysequence analysisepidemiologic studypathogen
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 274-278 )