Research advances in novel nucleos(t)ide analogues against HBV
LI Qiang
ZHUO Qi-bin
CHEN Liang
Abstract：A number of novel nucleos(t)ide analogues against HBV have been developed in recent years, some of which have been marketed abroad and some are currently under clinical trials. As compared with anti-HBV nucleos(t)ide analogues used in clinical practice in China, the novel nucleos(t)ide analogues exhibit greater antiviral activity, lower incidence rate of drug resistance, better tole-rance in patients and other advantages, however, there remain some problems, such as a high risk of recurrence after these nucleos (t)ide analogues are discontinued and increased resistance rates as treatment is prolonged. This review focuses on the research advances in novel anti-HBV nucleos(t)ide analogues in hope that clinicians may have a deeper knowledge of nucleos(t)ide analogues so as to provide more options for antiviral therapy for patients with chronic hepatitis B.
Keywords：hepatitis B virushepatitis Bchronicantiviral agents
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 233-236 )