Diagnostic value of FibroScan for liver fibrosis in patients with chronic hepatitis B
WANG Chun-ying
WANG Ji
JIA Bing-wen
LI Chun-yan
LIU Cheng-yong
Abstract：Objective To investigate the diagnostic value of FibroScan for liver fibrosis in patients with chronic hepatitis B (CHB). Methods Liver stiffness measurement using FibroScan was performed on 80 CHB patients, who had undergone histologic examination, and the values of liver stiffness measurement were recorded. No or mild liver fibrosis was defined as stage score 0-1, significant fibrosis as stage score 2-4, severe fibrosis as stage score 3-4 and early cirrhosis as stage score 4. With the results of liver biopsy as gold standard, the receiver-operating characteristic (ROC) curves were drawn, and the areas under ROC curves (AUROC) were calculated, so as to assess the diagnostic value of FibroScan for liver fibrosis in CHB patients. Results The value of liver stiffness measurement was positively correlated to liver fibrosis stage (rs=0.739, P<0.01); the AUROC were 0.865 for significant fibrosis, 0.940 for severe fibrosis and 0.944 for early cirrhosis. Conclusions FibroScan examination can accurately estimate the degree of liver fibrosis in CHB patients, and partly substitute liver biopsy, which is invasive. It is of great importance in the diagnosis and treatment of liver fibrosis in CHB patients.
Keywords：liver fibrosishepatitis Bchronicelasticity imaging techniqueshardness
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 226-228 )