Clinical features of liver injury in adult patients with hemophagocytic syndrome
LV Sa
YU Shuang-jie
BI Jing-feng
GENG Hua
CHEN Li-ming
Abstract：Objective To investigate the clinical features of liver injury in adult patients with hemophagocytic syndrome (HPS). Methods The etiology, clinical features and laboratory findings of 33 adult patients with HPS were analyzed retrospec-tively. Results Among 33 patients, the etiology related to infections was found in 17 (51.5%) patients, the etiology related to non-infections was found in 8 (24.2%) patients, and no underlying disease was found in 8 (24.2%) patients. Sixteen patients died, with the mortality rate of 48.5%. Different degrees of liver injury were observed in all the patients, manifested by an obvious in-crease in the activity of LDH and AST level and an obvious decline in ALB level, as well as an increase in TBIL level, mainly in DBIL, and a different degree of decrease in PA. However, only TBIL and PA were significantly different between the non-sur-vivor group and the survivor group (TBIL 307.3±182.2μmol/L vs 137.0±153.7μmol/L, P=0.013;PA 44.5%±18.8%vs 64.9%±19.1%, P=0.004). Conclusions Liver injury is a common organ damage in HPS patients, and the degree of liver injury may be related to the prognosis.
Keywords：lymphohistiocytosishemophagocyticliver diseasesdisease attributesprognosisadult
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 216-218 )