Drug resistance mutations in AIDS patients failing highly active antiretroviral therapy in Lincang, Yunnan province, in 2012
YANG Xi-ran
YANG Cui-xian
YANG Shao-min
BIAN Zhong-qi
Abstract：Objective To investigate HIV drug resistance mutations in AIDS patients failing highly active antiretroviral therapy (HAART) in Lincang, Yunnan province, in 2012. Methods Epidemiological characteristics of AIDS patients failing in HAART were investigated. CD4+T lymphocyte count and viral load were detected, and HIV-1 resistance testing was conducted on those patients with viral load more than 1000 copies/ml. Results Among 66 patients failing in HAART, drug resistance mutations were found in 53 patients. The most common nucleoside reverse transcriptase inhibitor resistance mutations were M184V, D67N and K70R, and non-nucleoside reverse transcriptase inhibitor resistance mutations were K103N, G190A and V179D. Only 3 protease inhibitor (P I ) resistance mutations were found, and they were D33F, M46I and L76V, respectively. Conclusions The emergence of reverse transcriptase resistance mutations is the main reason for the failure of first-line antiretroviral therapy (ART) in AIDS patients in Lincang, Yunnan province. Therefore, when switching to second-line ART, the increased use of PI can avoid ART failure due to multidrug resistance.
Keywords：acquired immunodeficiency syndromeantiretroviral therapyhighly activedrug resistance
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 164-166 )