Pathogenic characteristics and the prognosis in 1405 cirrhotic patients complicated by bacteremia

CHEN Su-ming; CUI En-bo; XIONG Yi-ru; BAO Chun-mei; JIA Tian-ye; WANG Huan; ZHANG Cheng-long; ZHANG Ju-ling; PANG Jun-li; QU Fen; MAO Yuan-li

Abstract：Objective To analyze the pathogenic characteristics and the prognosis of cirrhotic patients with bacteremia, so as to provide evidence for effective clinical treatment. Methods The clinical data of cirrhotic patients with clinical signs of bacteremia and blood culture positive, who were treated in our hospital during 2011-2013, were analyzed retrospectively. The pathogenic characteristics and prognosis of the patients were analyzed as well. Results Of 12 307 cirrhotic patients undergoing blood culture during 2011-2013, 1405 (11.42%) were blood culture positive. Pathogenic bacteria included 729 (51.89%) strains of gram-negative bacilli, 604 (42.99%) strains of gram-positive cocci, 51 (3.63%) strains of fungi and 21 (1.49%) strains of other bacteria . The proportions of the patients receiving abdominal punctuation (25.69%), invasive treatment of liver cancer (18.65%), venous catheter (16.65%) and indwelling urinary catheter (16.16%), and suffering from diabetes (5.12%) in bacteremia group were significantly higher than those of the control group (P<0.05). The mortality rate of gram-negative bacilli group (19.34%) was significantly higher than that of gram-positive cocci group (6.46%) (P<0.05). The mortality rates of Acinetobacter baumannii infection (56.52%) and Paeudomomas aeruginosa infection (58.62%) were significantly higher than that of Escherichia coli infection (30.23%) (P<0.05). Conclusions Gram-negative bacilli are the most frequent bacteria in cirrhotic patients with bacteremia. The prognosis is different in infections caused by different bacteria. Those patients receiving abdominal punctuation, invasive treatment of liver ca0ncer and venous catheter, and suffering from diabetes are more likely to develop bacteremia.