Carbapenem resistence and treatment challenges
NIE Shu-ping
LU Xue-dong
Abstract：Carbapenems were once considered the last line of defense against serious infections with gram-negative pathogens. As carbapenemases are spreading, the incidence of carbapenem-resistant isolates is increasing. The rise of carbapenem resistance in these pathogens carrying additional resistance genes to multiple antibiotic classes has created a generation of organisms nearly resis-tant to all available therapy and the infections caused by these pathogens have been associated with high mortality rates. This review focuses on the current status and mechanisms of carbapenem resistance, and the treatment of related infections.
Keywords：penicilliumanti-bacterial agentsdrug tolerancetherapeutics
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 134-138 )